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For heart disease Another significant benefit of berberine is its protection against heart disease.22 While we don’t know for sure if it can stop heart failure, we do know that it can decrease the likelihood of arrhythmias, atherosclerosis, abdominal aortic aneurysms, cardiac hypertrophy (a step toward heart failure), ischemic heart disease, and strokes.23 Furthermore, berberine plays a role in decreasing total cholesterol, LDL cholesterol, and blood triglycerides while increasing HDL (“good”) cholesterol.24 25 It also lowers high blood pressure, supporting good heart health from multiple angles