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Through its effects on IGFBP-1 and subsequently free IGF-I, intra-portal insulin exerts its effects to influence endogenous GH secretion via the negative feedback loop

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It bypasses first-pass hepatic metabolism — which oral delivery does not — allowing a greater proportion of the absorbed peptide to remain intact as it enters circulation.7 The olfactory pathway also provides a potential direct nose-to-brain route, bypassing the blood-brain barrier — a property that has generated interest for neuropeptides and potential neurological applications