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The interactome of NNMT We examined the interacting proteins of NNMT using the STRING database [35] ( showing that NNMT interacts with the following proteins including caveolae-associated protein 1 (PTRF), aldehyde oxidase (AOX1), epidermal growth factor receptor (EGFR), four and a half LIM domains protein 2 (FHL2), nicotinamide phosphoribosyltransferase (NAMPT), NAD-dependent protein deacetylase sirtuin 1-7 (SIRT1-7), ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (BST1), and ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) in human and mice
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The selective mechanism that avoids systemic hormonal disruption suggests potential for extended use compared to interventions that create metabolic or endocrine imbalances requiring periodic breaks
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