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Age effects and folate status, a modifier of vitamin B 12 metabolism, are also considered (Fedosov et al., 12 status, cB 12 , is defined as: cB 12 = log10((holo-TC.B 12 )/(MMA.tHcy))−(age factor) (Fedosov et al., 12 status provides five distinct ranges of diagnostic value, which are summarized in Table 1

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